700,000+ people experiencing relief with Signal Relief
The body speaks in signals. We’ve learned to listen.
Every product we make is backed by years of research into how the body communicates discomfort. Our patent-pending technology works with your body, not against it – no pills, probes, or prescriptions required. We are now on a second generation Signal Relief patch product, with excellent results being established on both generations.
You shouldn’t have to choose between effective results and a drug-free life.
of participants with back and knee pain experienced relief after 72 hours of using Signal Relief
of participants experienced a reduction in their pain
You shouldn’t have to choose between effective results and a drug-free life.
In a thermographic case study conducted at a medical clinic, the Signal Relief Patch reduced inflammation markers by up to 1.6°C in the treatment area within 3 days – with patients reporting noticeable relief.
Before
After
In a consumer study of people suffering from foot discomfort, Signal Step delivered measurable results fast:
Within 15 minutes
discomfort reduced by 32.7%
After 24 hours
over 57% reduction in pain scores
At 72 hours
more than 85% of users experienced relief
In a consumer study of people suffering from foot discomfort, Signal Step delivered measurable results fast:
In an IRB-approved pilot study published in Anesthesia & Pain Research, conducted on the first generation Signal Relief patch, patients with chronic musculoskeletal pain experienced dramatic results over just 7 days with the patch. View Study
Average reduction in pain scores
Reduction in OTC pain medication use
Reduction in opioid use
Zero adverse events reported
Trusted by doctors
“Based on clinical data, I believe this product will be at the forefront of change for healthy, non-addictive relief.”
"As an anesthesiologist and pain management specialist, I can see the Signal Relief Patch being used in a variety of circumstances and pain conditions, both in long-term and short-term pain."
“The Signal Relief patch has helped many of my patients with their chronic discomfort and has helped them return to an active lifestyle.”
"We all suffer from pain, we all hurt, and we all could benefit from the Signal Patch."
"I've spent a career helping patients who just wanted relief, and now there is another way. The Signal Relief Patch has changed my professional life."
In a placebo-controlled clinical study of 112 people with chronic back and knee pain, Signal Relief outperformed placebo at every measurement point:
felt relief within 15 minutes
average pain reduction
pain reduction for knee pain
experienced relief within 72 hours
Zero adverse events. Zero drugs.
In a placebo-controlled clinical study of 112 people with chronic back and knee pain, Signal Relief outperformed placebo at every measurement point:
In a clinical study of 91 people with chronic knee and lower back pain, Signal Relief delivered measurable results using gold-standard assessment tools:
felt relief within just 15 minutes
reported sustained relief at 72 hours
experienced relief at some point within 72 hours
No drugs. No adverse events.
In a clinical study of 91 people with chronic knee and lower back pain, Signal Relief delivered measurable results using gold-standard assessment tools:
700,000+ people experiencing relief with Signal Relief
Frequently Asked Questions
Clinical and consumer studies indicate that Signal Relief products can significantly reduce the impact of major discomfort in multiple situations. In placebo-controlled research involving individuals with chronic back and knee discomfort, up to 98% of participants experienced relief within 72 hours, while many reported noticeable improvements within just 15 minutes. These findings are supported by both first- and second-generation patch data. 📄 Knee and Back Study Summary – Placebo Controlled (Dr. Beth DuPree) 📄 Knee and Back Study Summary – Dr. Arup Sen 📄 Signal Relief White Paper (2026)
Study data suggests that many users begin to feel relief quickly. In clinical and consumer trials, between 63% and 71% of participants reported relief within 15 minutes of application. Continued use over 24 to 72 hours resulted in progressively greater reductions in pain scores. 📄 Knee and Back Study Summary – Placebo Controlled (Dr. Beth DuPree) 📄 Knee and Back Study Summary – Dr. Arup Sen
Multiple studies — including an IRB-approved pilot study published in Anesthesia & Pain Research — demonstrate effectiveness for chronic musculoskeletal issues. Participants in that study experienced an average 60% reduction in scores over 7 days, along with substantial decreases in reliance on over-the-counter and opioid medications. 📄 Medical Journal: Anesthesia & Pain Research – Published Clinical Study 📄 Signal Relief White Paper (2026)
Thermographic imaging in a clinical case study showed that the Signal Relief Patch reduced inflammation markers by up to 1.6°C within three days. This measurable decrease in localized inflammation was accompanied by patient-reported improvements in discomfort levels. 📄 Thermographic Images Case Study – August 2025
Across multiple studies, including placebo-controlled trials and pilot research, no adverse events were reported. Signal Relief products are drug-free and non-invasive, making them a potential option for individuals seeking alternatives to medications or invasive treatments. 📄 Knee and Back Study Summary – Placebo Controlled (Dr. Beth DuPree) 📄 Medical Journal: Anesthesia & Pain Research – Published Clinical Study
In placebo-controlled studies, Signal Relief consistently outperformed placebo across all measurement points. Participants using the patch reported faster onset of relief, greater overall discomfort reduction, and more sustained results over 72 hours compared to those using placebo treatments. 📄 Knee and Back Study Summary – Placebo Controlled (Dr. Beth DuPree) 📄 Medical Journal: Anesthesia & Pain Research – Published Clinical Study
