New Study: Signal Relief™ Patch for Musculoskeletal Pain Relief

by Daniel Marriott

Participants reported up to 45% less pain and over 90% felt relief within 72 hours — without side effects.

When it comes to pain relief, people considering Signal Relief often ask: “Does it really work?”. Now, we have new data that helps answer it. 

A recent white paper prepared by Dr. Beth DuPree, Medical Advisor to Relief Sciences U.S.A., reviewed outcomes for more than 100 people living with chronic back and knee pain. The results show that the Signal Relief™ Patch provided meaningful, drug-free relief for most participants.

The Problem: Chronic Back and Knee Pain

  • 16 million U.S. adults live with persistent back pain (about 8%).

  • Over 64 million adults live with ongoing knee pain (about 25%).

This kind of pain often limits mobility and reduces quality of life. While treatments like exercise, physical therapy, or mindfulness may help, their effectiveness is often limited. Medications, on the other hand, can work, but may bring risks like GI bleeding, kidney injury, dependency, or addiction.

The White Paper Findings

The white paper reviewed clinical data from 112 adults experiencing chronic back or knee pain. Participants were randomized in a double-blind, placebo-controlled design, where most received active Signal Relief™ Patches and a smaller group received placebo.

Here’s what the study found:

Overall Pain Relief

  • Participants with the active patch experienced an average 42% pain reduction, compared to 34% in the placebo group.

Knee Pain Relief

  • The knee pain group saw 45% average reduction, with benefits continuing to improve across the 72-hour window.

Speed of Relief

  • 71% of active group participants felt relief within 15 minutes.

  • 98% felt relief at some point within 72 hours.

Safety

  • No adverse events were reported.

An infographic on Signal Relief findings: 71% of users felt relief in 15 minutes, with a 42% average overall pain reduction and no adverse events reported.

Earlier Published Research

This isn’t the first time bio-antenna patch technology has been studied. Earlier published research on similar patch technology, appearing in Anesthesia & Pain Research (2023), also reported significant reductions in musculoskeletal pain and decreased medication use.

While that pilot study involved a different generation of the technology, its findings provide additional scientific context that supports the potential of this drug-free, non-invasive approach to pain relief.

Study results: 75% had at least 30% less pain, average pain dropped 60%, over 90% felt better, non-opioid use fell 96.5%, opioid use fell 91.4%, no side effects reported.

How Signal Relief Works

So how can a simple patch make such a difference?

The Signal Relief™ Patch contains a micro-antenna array— a conductive structure that interacts with the body’s own electrical signals. When placed on or near the source of pain, this interaction may help reduce the “noise” of pain signals before they reach the brain.

The result? A sensation of relief without drugs, wires, or batteries.

The Takeaway

Based on this published white paper and earlier study:

  • The majority of participants experienced meaningful pain reduction.

  • Many reported relief within hours, with almost all feeling relief within days.

  • The patch was well tolerated, safe, and drug-free.

These findings give consumers clear, scientifically backed evidence supporting Signal Relief™ as a safe, drug-free option for musculoskeletal pain relief.

If you’re ready to explore pain relief backed by science, learn more about Signal Relief™ today.

 

Dr. Beth Baughman DuPree, MD, FACS, ABOIM

About Dr. Beth Baughman DuPree, MD, FACS, ABOIM

Dr. Beth Baughman DuPree, MD, FACS, ABOIM, is a board-certified surgeon and integrative medicine physician. She serves as Medical Advisor to Relief Sciences U.S.A., where she helps guide research and development of innovative, drug-free health technologies.

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